Medicine

Evolving ASO therapies coming from growth to application

.Completing interests.R.S., M.S., H.G. and A.A.R. are planners of the 1M1M project. H.G. and also A.A.R. are actually panel of supervisors participants and R.S., M.S. and also A.A.R. are actually members of the clinical consultatory committee of N1C. A.A.R. discloses work by LUMC, which has licenses on exon-skipping modern technology, several of which has actually been accredited to BioMarin and ultimately sublicensed to Sarepta. As co-inventor of some of these licenses, A.A.R. was actually qualified to a share of aristocracies. A.A.R. even further reveals acting as ad hoc consultant for PTC Therapeutics, Sarepta Therapeutics, Regenxbio, Dyne Therapeutics, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and also Astra Zeneca. Over the last 5 years, A.A.R. additionally conducted speaking to for Alpha Anomeric. A.A.R. additionally discloses subscription of the scientific advisory boards of Eisai, Hybridize Rehabs, Silence Therapies, Sarepta Therapeutics, Sapreme and Mitorx. Previously 5 years, A.A.R. was actually likewise a clinical advisory board member for ProQR. Remuneration for A.A.R. u00e2 s consulting and encouraging tasks is spent to LUMC. In the past 5 years, LUMC additionally received sound speaker gratuity from PTC Therapies, Alnylam Netherlands, Italfarmaco as well as Pfizer as well as funding for contract research coming from Sapreme, Eisai, Galapagos, Synaffix and also Alpha Anomeric. Project financing is received from Sarepta Therapies and also Entrada through unconstrained grants. H.G. has absolutely nothing to reveal in relation to the subjects covered in this composition. Previously 5 years, he has actually likewise gotten working as a consultant gratuity coming from UCB. M.S. got working as a consultant gratuity from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa in the past 5 years, all unrelated to today composition. R.S. possesses absolutely nothing to divulge in relation to the topics covered in this particular composition. She has actually obtained audio speaker and/or working as a consultant gratuity or funding additions coming from Abbvie, Bial, STADA as well as Everpharma before 5 years.